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Institute of Applied Physics
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Project CSSDT 14.820.18.04.05/U Synthesis, properties, molecular and crystal structure of benzodiazepine and fibrinogen receptor ligands

Type : Bilateral project SCSTD (ASM) - State Agency on Science, Innovations and Informatization of Ukraine # 14.820.18.04.05/U, acronym - SARBEFIR
Head : Victor Kravtsov, Ph.D.
Duration : 2014 - 2015
Division : Laboratory of Physical Methods of Solid State Investigation “Tadeusz Malinowski”

       The aim of the project was to study of the “structure - properties - molecular mechanism of action” relationship for new potential ligands of benzodiazepine and fibrinogen receptors, which are promising medical neurotropic drags for the prevention and treatment of psychoneurotic disorders and potential antiaggregative agents for the prevention and treatment of cardiovascular diseases. Teams of the Institute of Applied Physics and Physico-chemical institute intend to synthesize, carried out investigations of  the structure, conformational features, the nature of intermolecular interactions in the crystal, and affinity of the novel ligands of the benzodiazepine and fibrinogen receptors and their pharmacological properties. The relevance of the project is determined by the importance and potential of 3-substituted dihydro-1,4-benzodiazepine as neurotropic and  psychotropic drugs and ligands of fibrinogen receptor (integrin αIIbβ3) as inhibitors of platelets aggregation, which can be used for the prevention and treatment of dangerous cardiovascular diseases such as atherosclerosis, stenocardia, myocardial infarction, stroke and thromboembolism.

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